Thursday’s game between the No. 25 Louisville Cardinals (19-8) and the Clemson Tigers (13-14) at KFC Yum! Center is expected to be a lopsided matchup, as our computer prediction projects a final score of 74-61 and heavily favors Louisville to secure the victory. Game time is at 6 p.m. ET on February 27.

According to our computer prediction, Louisville is a good bet to cover the spread, which is listed at 10.5. The two sides are projected to go over the 134.5 over/under.

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Louisville vs. Clemson Game Info & Odds

• Date: Thursday, February 27, 2025
• Time: 6 p.m. ET
• TV channel: ACC Network
• Live stream: Watch this game on Fubo (Regional restrictions may apply)
• Where: Louisville, Kentucky
• Venue: KFC Yum! Center
• Line: Louisville -10.5
• Point total: 134.5
• Moneyline (to win): Louisville -800, Clemson +550

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Louisville vs. Clemson Score Prediction

• Prediction:
  Louisville 74, Clemson 61

Spread & Total Prediction for Louisville vs. Clemson

• Pick ATS: Louisville (-10.5)
• Pick OU: Over (134.5)

Louisville’s record against the spread so far this season is 10-9-0, and Clemson’s is 8-7-0. A total of nine out of the Cardinals’ games this season have gone over the point total, and four of the Tigers’ games have gone over. The two teams combine to score 139.5 points per game, 5.0 more points than this matchup’s total. Louisville is 6-4 against the spread and 7-3 overall over its last 10 games, while Clemson has gone 5-5 against the spread and 3-7 overall.

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Louisville Performance Insights

• The Cardinals outscore opponents by 5.5 points per game (scoring 73.4 points per game to rank 59th in college basketball while allowing 67.9 per contest to rank 260th in college basketball) and have a +150 scoring differential overall.
• Louisville prevails in the rebound battle by an average of 2.8 boards. It is recording 32.9 rebounds per game (137th in college basketball) compared to its opponents’ 30.1 per contest.
• Louisville knocks down 6.1 three-pointers per game (180th in college basketball) compared to its opponents’ 5.9. It shoots 31.8% from deep while its opponents hit 33.0% from long range.
• The Cardinals rank 89th in college basketball by averaging 88.5 points per 100 possessions on offense, and defensively are 193rd in college basketball, allowing 81.8 points per 100 possessions.
• Louisville has committed 3.6 fewer turnovers per game than its opponents, averaging 15.3 (179th in college basketball action) while forcing 18.9 (39th in college basketball).

Clemson Performance Insights

• The Tigers’ +74 scoring differential (outscoring opponents by 2.7 points per game) is a result of putting up 66.1 points per game (162nd in college basketball) while giving up 63.4 per outing (153rd in college basketball).
• Clemson is 211th in the country at 31.4 rebounds per game. That’s 1.9 more than the 29.5 its opponents average.
• Clemson connects on 7.5 three-pointers per game (68th in college basketball), 1.8 more than its opponents.
• Clemson and its opponents have been relatively even in the turnover battle. The Tigers commit 13.0 per game (49th in college basketball) and force 12.3 (340th in college basketball).

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