Wednesday’s game that pits the No. 13 Clemson Tigers (22-5, 14-2 ACC) against the Notre Dame Fighting Irish (12-15, 6-10 ACC) at Littlejohn Coliseum is expected to be a one-sided matchup based on our computer prediction, which projects a final score of 79-66 in favor of Clemson, who is heavily favored by our model. Tipoff is at 7:00 PM ET on February 26.

Based on our computer prediction, Clemson projects to cover the 12.5-point spread in its matchup against Notre Dame. The total has been set at 138.5, and the two sides are projected to hit the over.

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Clemson vs. Notre Dame Game Info & Odds

• Date: Wednesday, February 26, 2025
• Time: 7:00 PM ET
• TV: ACC Network
• Live stream: Watch this game on Fubo (Regional restrictions may apply)
• Where: Clemson, South Carolina
• Venue: Littlejohn Coliseum
• Line: Clemson -12.5
• Point total: 138.5
• Moneyline (to win): Clemson -901, Notre Dame +590

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Clemson vs. Notre Dame Score Prediction

• Prediction:
  Clemson 79, Notre Dame 66

Spread & Total Prediction for Clemson vs. Notre Dame

• Pick ATS: Clemson (-12.5)
• Pick OU: Over (138.5)

Clemson is 17-10-0 against the spread this season compared to Notre Dame’s 13-14-0 ATS record. The Tigers have a 14-13-0 record going over the point total, while games involving the Fighting Irish have a record of 13-14-0 when it comes to hitting the over. The teams score an average of 150.8 points per game, 12.3 more points than this matchup’s total. Clemson is 8-2 against the spread and 9-1 overall in its last 10 games, while Notre Dame has gone 2-8 against the spread and 4-6 overall.

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Clemson Performance Insights

• The Tigers’ +297 scoring differential (outscoring opponents by 11.0 points per game) is a result of scoring 77.5 points per game (87th in college basketball) while giving up 66.5 per contest (43rd in college basketball).
• Clemson ranks 167th in the nation at 32.4 rebounds per game. That’s 2.7 more than the 29.7 its opponents average.
• Clemson makes 9.2 three-pointers per game (56th in college basketball), 2.0 more than its opponents (7.2).
• The Tigers average 102.2 points per 100 possessions on offense (43rd in college basketball), and allow 87.7 points per 100 possessions (53rd in college basketball).
• Clemson has committed 10.1 turnovers per game (69th in college basketball action), 2.4 fewer than the 12.5 it forces on average (88th in college basketball).

Notre Dame Performance Insights

• The Fighting Irish’s +38 scoring differential (outscoring opponents by 1.4 points per game) is a result of putting up 73.3 points per game (206th in college basketball) while giving up 71.9 per outing (184th in college basketball).
• Notre Dame is 234th in the country at 31.2 rebounds per game. That’s 2.6 more than the 28.6 its opponents average.
• Notre Dame knocks down 7.9 three-pointers per game (158th in college basketball) at a 36.2% rate (67th in college basketball), compared to the 7.6 its opponents make, shooting 32.2% from beyond the arc.
• Notre Dame and its opponents have been mostly even in the turnover battle. The Fighting Irish commit 10.3 per game (88th in college basketball) and force 9.8 (323rd in college basketball).

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