Top 25 College Hoops Picks Against the Spread – Friday, February 21

Published 1:28 am Friday, February 21, 2025

Top-25 teams will take the court across two games on Friday’s college basketball schedule. That includes the Michigan State Spartans taking on the Michigan Wolverines at Crisler Center. Looking for against-the-spread picks? See below.

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AP Top 25 Picks ATS Today

Villanova Wildcats vs. No. 16 Marquette Golden Eagles

Spread Prediction

  • Computer Prediction: Marquette 73, Villanova 70
  • Projected Favorite: Marquette by 3.5 points
  • Pick ATS: Marquette (-1.5)

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Bet on the Villanova-Marquette spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7 p.m. ET
  • Location: Philadelphia, Pennsylvania
  • Venue: Wells Fargo Center
  • TV Channel: Fox Sports 1
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 12 Michigan Wolverines vs. No. 14 Michigan State Spartans

Spread Prediction

  • Computer Prediction: Michigan 76, Michigan State 73
  • Projected Favorite: Michigan by 2.7 points
  • Pick ATS: Michigan (-2.5)

Bet on the Michigan-Michigan State spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 8 p.m. ET
  • Location: Ann Arbor, Michigan
  • Venue: Crisler Center
  • TV Channel: FOX
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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