Top 25 College Hoops Picks Against the Spread – Wednesday, February 19

Published 1:28 am Wednesday, February 19, 2025

Wednesday’s college basketball slate includes four games with a ranked team in play. Among those games is the Alabama Crimson Tide squaring off against the Missouri Tigers. Keep scrolling for ATS picks for each matchup.

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AP Top 25 Picks ATS Today

No. 17 Kentucky Wildcats vs. Vanderbilt Commodores

Spread Prediction

  • Computer Prediction: Kentucky 83, Vanderbilt 75
  • Projected Favorite: Kentucky by 8.3 points
  • Pick ATS: Kentucky (-5.5)

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Bet on the Kentucky-Vanderbilt spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 7 p.m. ET
  • Location: Lexington, Kentucky
  • Venue: Rupp Arena
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 15 Missouri Tigers vs. No. 4 Alabama Crimson Tide

Spread Prediction

  • Computer Prediction: Alabama 81, Missouri 79
  • Projected Favorite: Alabama by 2.4 points
  • Pick ATS: Alabama (+1.5)

Bet on the Missouri-Alabama spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9 p.m. ET
  • Location: Columbia, Missouri
  • Venue: Mizzou Arena
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

DePaul Blue Demons vs. No. 10 St. John’s Red Storm

Spread Prediction

  • Computer Prediction: St. John’s 78, DePaul 67
  • Projected Favorite: St. John’s by 10.6 points
  • Pick ATS: DePaul (+12.5)

Bet on the DePaul-St. John’s spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9 p.m. ET
  • Location: Chicago, Illinois
  • Venue: Wintrust Arena
  • TV Channel: Fox Sports 1
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 1 Auburn Tigers vs. Arkansas Razorbacks

Spread Prediction

  • Computer Prediction: Auburn 82, Arkansas 67
  • Projected Favorite: Auburn by 14.9 points
  • Pick ATS: Arkansas (+15.5)

Bet on the Auburn-Arkansas spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 9 p.m. ET
  • Location: Auburn, Alabama
  • Venue: Neville Arena
  • TV Channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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