Thursday’s game between the No. 10 Duke Blue Devils (17-5) and the Clemson Tigers (11-11) at Cameron Indoor Stadium has a good chance to be a lopsided matchup, as our computer prediction projects a final score of 78-55 and heavily favors Duke to take home the win. Game time is at 7:00 PM ET on February 6.

Based on our computer prediction, Duke projects to cover the 22.5-point spread in its matchup versus Clemson. The over/under is currently listed at 130.5, and the two sides are projected to hit the over.

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Duke vs. Clemson Game Info & Odds

• Date: Thursday, February 6, 2025
• Time: 7:00 PM ET
• TV channel: ACC Network X
• Where: Durham, North Carolina
• Venue: Cameron Indoor Stadium
• Line: Duke -22.5
• Point total: 130.5

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Duke vs. Clemson Score Prediction

• Prediction:
  Duke 78, Clemson 55

Spread & Total Prediction for Duke vs. Clemson

• Pick ATS: Duke (-22.5)
• Pick OU: Over (130.5)

Duke has gone 11-8-0 against the spread, while Clemson’s ATS record this season is 4-7-0. The Blue Devils have gone over the point total in eight games, while Tigers games have gone over four times. The teams score an average of 143.4 points per game, 12.9 more points than this matchup’s total. Duke has a 6-4 record against the spread while going 7-3 overall in the past 10 games. Clemson has gone 4-6 against the spread and 3-7 overall in its last 10 games.

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Duke Performance Insights

• The Blue Devils outscore opponents by 16.6 points per game (scoring 76.1 points per game to rank 40th in college basketball while allowing 59.5 per outing to rank 75th in college basketball) and have a +365 scoring differential overall.
• Duke prevails in the rebound battle by an average of 8.7 boards. It is collecting 36.2 rebounds per game (32nd in college basketball) compared to its opponents’ 27.5 per outing.
• Duke makes 6.4 three-pointers per game (157th in college basketball) at a 36.0% rate (24th in college basketball), compared to the 4.3 per game its opponents make at a 28.7% rate.
• The Blue Devils put up 90.7 points per 100 possessions (72nd in college basketball), while allowing 71.0 points per 100 possessions (31st in college basketball).
• Duke has had fewer turnovers than its opponents this season, committing 14.7 per game (124th in college basketball play) while forcing 19.3 (35th in college basketball).

Clemson Performance Insights

• The Tigers’ +75 scoring differential (outscoring opponents by 3.4 points per game) is a result of putting up 67.3 points per game (144th in college basketball) while giving up 63.9 per contest (165th in college basketball).
• Clemson grabs 31.7 rebounds per game (206th in college basketball) while conceding 29.2 per outing to opponents. It outrebounds opponents by 2.5 boards per game.
• Clemson makes 7.5 three-pointers per game (65th in college basketball) at a 35.1% rate (45th in college basketball), compared to the 5.6 per game its opponents make, at a 32.3% rate.
• Clemson forces 12.1 turnovers per game (341st in college basketball) while committing 12.9 (41st in college basketball).

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