Tuesday’s contest between the Louisville Cardinals (10-5, 3-1 ACC) and Clemson Tigers (12-3, 4-0 ACC) matching up at KFC Yum! Center has a projected final score of 75-72 (based on our computer prediction) in favor of Louisville, who is listed as a small favorite by our model. The game will start at 7:00 PM ET on January 7.

According to our computer prediction, the Louisville versus Clemson matchup has a predicted point spread that matches the actual spread (3.5). The two teams are projected to eclipse the 145.5 total.

Watch men’s college basketball, other live sports and more on Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Use our link to sign up.

Louisville vs. Clemson Game Info & Odds

• Date: Tuesday, January 7, 2025
• Time: 7:00 PM ET
• TV: ESPNU
• Live stream: Watch this game on Fubo (Regional restrictions may apply)
• Where: Louisville, Kentucky
• Venue: KFC Yum! Center
• Line: Louisville -3.5
• Point total: 145.5
• Moneyline (to win): Louisville -162, Clemson +132

Place your bets on any men’s college basketball matchup at BetMGM. Sign up today using our link.

Louisville vs. Clemson Score Prediction

• Prediction:
  Louisville 75, Clemson 72

Spread & Total Prediction for Louisville vs. Clemson

• Pick ATS: Pick Em
• Pick OU: Over (145.5)

Both Louisville and Clemson are 8-7-0 against the spread (ATS) so far this season. The Cardinals have a 4-11-0 record hitting the over, while games involving the Tigers have a record of 8-7-0 when it comes to hitting the over. The two teams score an average of 156.3 points per game, 10.8 more points than this matchup’s total. Louisville has a 5-5 record against the spread while going 6-4 overall in the past 10 contests. Clemson has gone 6-4 against the spread and 8-2 overall in its last 10 games.

Bet on this or any men’s college basketball matchup at BetMGM.

Louisville Performance Insights

• The Cardinals are outscoring opponents by 7.7 points per game with a +115 scoring differential overall. They put up 77.8 points per game (120th in college basketball) and give up 70.1 per contest (150th in college basketball).
• The 36.4 rebounds per game Louisville averages rank 39th in the nation, and are 6.8 more than the 29.6 its opponents collect per contest.
• Louisville hits 9.3 three-pointers per game (66th in college basketball), 1.6 more than its opponents (7.7).
• The Cardinals rank 130th in college basketball by averaging 98.5 points per 100 possessions on offense, and defensively are 131st in college basketball, allowing 88.8 points per 100 possessions.
• Louisville has won the turnover battle by 1.9 turnovers per game, committing 11.2 (152nd in college basketball action) while forcing 13.1 (93rd in college basketball).

Clemson Performance Insights

• The Tigers have a +175 scoring differential, topping opponents by 11.6 points per game. They’re putting up 78.5 points per game, 109th in college basketball, and are giving up 66.9 per contest to rank 74th in college basketball.
• Clemson prevails in the rebound battle by an average of 4.1 boards. It grabs 33.1 rebounds per game (176th in college basketball) compared to its opponents’ 29.0.
• Clemson connects on 2.0 more threes per game than the opposition, 8.9 (90th in college basketball) compared to its opponents’ 6.9.
• Clemson wins the turnover battle by 2.6 per game, committing 10.7 (102nd in college basketball) while its opponents average 13.3.

Rep your favorite players with officially licensed gear. Head to Fanatics to find jerseys, shirts, hats, and much more.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.