Our computer model predicts the No. 11 Clemson Tigers will defeat the Louisville Cardinals on Saturday, Nov. 2 at 7:30 p.m. ET. For a complete projection on the game at Memorial Stadium (Clemson, SC), which includes our prediction on the spread, over/under, and final score, keep scrolling.

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Clemson vs. Louisville Predictions and Picks

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Clemson Betting Info (2024)

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• Based on this game’s moneyline, the Tigers’ implied win probability is 79.8%.
• The Tigers have covered the spread four times in seven games.
• In games this season when favored by 10.5 points or more, Clemson are 4-2 against the spread.
• Out of seven Tigers games so far this year, three have gone over the total.
• The over/under in this game is 62 points, 8.9 higher than the average total in Clemson games this season.

Louisville Betting Info (2024)

• The Cardinals have a 24.8% chance to win this game based on the implied probability of the moneyline.
• The Cardinals is 2-5-0 against the spread this season.
• In the Cardinals’ seven games with a set total, five have hit the over (71.4%).
• The average total for Louisville games this season is 7.3 less points than the point total of 62 for this outing.

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Tigers vs. Cardinals 2024 Scoring Averages

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