Among the options on the Week 5 ACC college football schedule, Stanford (+21.5) against Clemson is our best bet on the spread, while our model suggests betting on the total in the Stanford vs. Clemson matchup. Get even more stats and insights on those and other games to wager on or include in a parlay in the article below.

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Best Week 5 ACC Spread Bets

Pick: Stanford +21.5 vs. Clemson

• Matchup: Stanford Cardinal at Clemson Tigers
• Projected Winner & Margin of Victory: Clemson by 6.7 points
• Date/Time: Sept. 28 at 7:00 PM ET
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Virginia Tech +19.5 vs. Miami (FL)

• Matchup: Virginia Tech Hokies at Miami (FL) Hurricanes
• Projected Winner & Margin of Victory: Miami (FL) by 7 points
• Date/Time: Sept. 27 at 7:30 PM ET
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Northern Illinois +6.5 vs. North Carolina State

• Matchup: Northern Illinois Huskies at North Carolina State Wolfpack
• Projected Winner & Margin of Victory: Northern Illinois by 0.3 points
• Date/Time: Sept. 28 at 12:00 PM ET
• TV Channel: The CW
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Western Kentucky +12.5 vs. Boston College

• Matchup: Western Kentucky Hilltoppers at Boston College Eagles
• Projected Winner & Margin of Victory: Boston College by 5.8 points
• Date/Time: Sept. 28 at 12:00 PM ET
• TV Channel: ACC Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Duke -2.5 vs. North Carolina

• Matchup: North Carolina Tar Heels at Duke Blue Devils
• Projected Winner & Margin of Victory: Duke by 5.3 points
• Date/Time: Sept. 28 at 4:00 PM ET
• TV Channel: ESPN2
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Use these spread picks at BetMGM today!

Best Week 5 ACC Total Bets

Over 57.5 – Stanford vs. Clemson

• Matchup: Stanford Cardinal at Clemson Tigers
• Projected Total: 63.9 points
• Date/Time: Sept. 28 at 7:00 PM ET
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 55.5 – North Carolina vs. Duke

• Matchup: North Carolina Tar Heels at Duke Blue Devils
• Projected Total: 61.5 points
• Date/Time: Sept. 28 at 4:00 PM ET
• TV Channel: ESPN2
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 47.5 – Northern Illinois vs. North Carolina State

• Matchup: Northern Illinois Huskies at North Carolina State Wolfpack
• Projected Total: 52.4 points
• Date/Time: Sept. 28 at 12:00 PM ET
• TV Channel: The CW
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 60.5 – Louisiana vs. Wake Forest

• Matchup: Louisiana Ragin’ Cajuns at Wake Forest Demon Deacons
• Projected Total: 56.3 points
• Date/Time: Sept. 28 at 3:30 PM ET
• TV Channel: ACC Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 55.5 – Western Kentucky vs. Boston College

• Matchup: Western Kentucky Hilltoppers at Boston College Eagles
• Projected Total: 51.8 points
• Date/Time: Sept. 28 at 12:00 PM ET
• TV Channel: ACC Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Take advantage of our picks and place your bet at BetMGM today!

Week 5 ACC Standings

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